A Preliminary Comparison of P-Tool Consistency

Javier Murillo; Flavio Spetale; Elizabeth Tapia; Flavia Krsticevic; Olivier Cailloux; Serge Guillaume; Gustavo Vazquez; Tamara Fernandez; Sebastien Destercke; Sergio Ponce; Pilar Bulacio

doi:10.1007/978-3-030-30648-9_97

A Preliminary Comparison of P-Tool Consistency

Javier Murillo
, Flavio Spetale
, Elizabeth Tapia
, Flavia Krsticevic
, Olivier Cailloux
, Serge Guillaume
, Gustavo Vazquez
, Tamara Fernandez
, Sebastien Destercke
, Sergio Ponce
, Pilar Bulacio

Department of Computer Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.

Original language	English
Title of host publication	8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019
Editors	César A. González Díaz, Christian Chapa González, Eric Laciar Leber, Hugo A. Vélez, Norma P. Puente, Dora-Luz Flores, Adriano O. Andrade, Héctor A. Galván, Fabiola Martínez, Renato García, Citlalli J. Trujillo, Aldo R. Mejía
Publisher	Springer
Pages	731-735
Number of pages	5
ISBN (Print)	9783030306472
DOIs	https://doi.org/10.1007/978-3-030-30648-9_97
State	Published - 2020
Event	8th Latin American Conference on Biomedical Engineering and the 42nd National Conference on Biomedical Engineering, CLAIB-CNIB 2019 - Cancún, Mexico Duration: 2 Oct 2019 → 5 Oct 2019

Publication series

Name	IFMBE Proceedings
Volume	75
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Conference

Conference	8th Latin American Conference on Biomedical Engineering and the 42nd National Conference on Biomedical Engineering, CLAIB-CNIB 2019
Country/Territory	Mexico
City	Cancún
Period	2/10/19 → 5/10/19

Keywords

Gene functionality
Missense nonsense mutation
SNP

Access to Document

10.1007/978-3-030-30648-9_97

Cite this

Murillo, J., Spetale, F., Tapia, E., Krsticevic, F., Cailloux, O., Guillaume, S., Vazquez, G., Fernandez, T., Destercke, S., Ponce, S., & Bulacio, P. (2020). A Preliminary Comparison of P-Tool Consistency. In C. A. González Díaz, C. Chapa González, E. Laciar Leber, H. A. Vélez, N. P. Puente, D.-L. Flores, A. O. Andrade, H. A. Galván, F. Martínez, R. García, C. J. Trujillo, & A. R. Mejía (Eds.), 8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019 (pp. 731-735). (IFMBE Proceedings; Vol. 75). Springer. https://doi.org/10.1007/978-3-030-30648-9_97

Murillo, Javier ; Spetale, Flavio ; Tapia, Elizabeth et al. / A Preliminary Comparison of P-Tool Consistency. 8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019. editor / César A. González Díaz ; Christian Chapa González ; Eric Laciar Leber ; Hugo A. Vélez ; Norma P. Puente ; Dora-Luz Flores ; Adriano O. Andrade ; Héctor A. Galván ; Fabiola Martínez ; Renato García ; Citlalli J. Trujillo ; Aldo R. Mejía. Springer, 2020. pp. 731-735 (IFMBE Proceedings).

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title = "A Preliminary Comparison of P-Tool Consistency",

abstract = "Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.",

keywords = "Gene functionality, Missense nonsense mutation, SNP",

author = "Javier Murillo and Flavio Spetale and Elizabeth Tapia and Flavia Krsticevic and Olivier Cailloux and Serge Guillaume and Gustavo Vazquez and Tamara Fernandez and Sebastien Destercke and Sergio Ponce and Pilar Bulacio",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG.; 8th Latin American Conference on Biomedical Engineering and the 42nd National Conference on Biomedical Engineering, CLAIB-CNIB 2019 ; Conference date: 02-10-2019 Through 05-10-2019",

year = "2020",

doi = "10.1007/978-3-030-30648-9\_97",

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isbn = "9783030306472",

series = "IFMBE Proceedings",

publisher = "Springer",

pages = "731--735",

editor = "\{Gonz{\'a}lez D{\'i}az\}, \{C{\'e}sar A.\} and \{Chapa Gonz{\'a}lez\}, Christian and \{Laciar Leber\}, Eric and V{\'e}lez, \{Hugo A.\} and Puente, \{Norma P.\} and Dora-Luz Flores and Andrade, \{Adriano O.\} and Galv{\'a}n, \{H{\'e}ctor A.\} and Fabiola Mart{\'i}nez and Renato Garc{\'i}a and Trujillo, \{Citlalli J.\} and Mej{\'i}a, \{Aldo R.\}",

booktitle = "8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019",

}

Murillo, J, Spetale, F, Tapia, E, Krsticevic, F, Cailloux, O, Guillaume, S, Vazquez, G, Fernandez, T, Destercke, S, Ponce, S & Bulacio, P 2020, A Preliminary Comparison of P-Tool Consistency. in CA González Díaz, C Chapa González, E Laciar Leber, HA Vélez, NP Puente, D-L Flores, AO Andrade, HA Galván, F Martínez, R García, CJ Trujillo & AR Mejía (eds), 8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019. IFMBE Proceedings, vol. 75, Springer, pp. 731-735, 8th Latin American Conference on Biomedical Engineering and the 42nd National Conference on Biomedical Engineering, CLAIB-CNIB 2019, Cancún, Mexico, 2/10/19. https://doi.org/10.1007/978-3-030-30648-9_97

A Preliminary Comparison of P-Tool Consistency. / Murillo, Javier; Spetale, Flavio; Tapia, Elizabeth et al.
8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019. ed. / César A. González Díaz; Christian Chapa González; Eric Laciar Leber; Hugo A. Vélez; Norma P. Puente; Dora-Luz Flores; Adriano O. Andrade; Héctor A. Galván; Fabiola Martínez; Renato García; Citlalli J. Trujillo; Aldo R. Mejía. Springer, 2020. p. 731-735 (IFMBE Proceedings; Vol. 75).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A Preliminary Comparison of P-Tool Consistency

AU - Murillo, Javier

AU - Spetale, Flavio

AU - Tapia, Elizabeth

AU - Krsticevic, Flavia

AU - Cailloux, Olivier

AU - Guillaume, Serge

AU - Vazquez, Gustavo

AU - Fernandez, Tamara

AU - Destercke, Sebastien

AU - Ponce, Sergio

AU - Bulacio, Pilar

PY - 2020

Y1 - 2020

N2 - Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.

AB - Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.

KW - Gene functionality

KW - Missense nonsense mutation

KW - SNP

UR - https://www.scopus.com/pages/publications/85075667943

U2 - 10.1007/978-3-030-30648-9_97

DO - 10.1007/978-3-030-30648-9_97

M3 - Contribución a la conferencia

AN - SCOPUS:85075667943

SN - 9783030306472

T3 - IFMBE Proceedings

SP - 731

EP - 735

BT - 8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019

A2 - González Díaz, César A.

A2 - Chapa González, Christian

A2 - Laciar Leber, Eric

A2 - Vélez, Hugo A.

A2 - Puente, Norma P.

A2 - Flores, Dora-Luz

A2 - Andrade, Adriano O.

A2 - Galván, Héctor A.

A2 - Martínez, Fabiola

A2 - García, Renato

A2 - Trujillo, Citlalli J.

A2 - Mejía, Aldo R.

PB - Springer

T2 - 8th Latin American Conference on Biomedical Engineering and the 42nd National Conference on Biomedical Engineering, CLAIB-CNIB 2019

Y2 - 2 October 2019 through 5 October 2019

ER -

Murillo J, Spetale F, Tapia E, Krsticevic F, Cailloux O, Guillaume S et al. A Preliminary Comparison of P-Tool Consistency. In González Díaz CA, Chapa González C, Laciar Leber E, Vélez HA, Puente NP, Flores DL, Andrade AO, Galván HA, Martínez F, García R, Trujillo CJ, Mejía AR, editors, 8th Latin American Conference on Biomedical Engineering and 42nd National Conference on Biomedical Engineering - Proceedings of CLAIB-CNIB 2019. Springer. 2020. p. 731-735. (IFMBE Proceedings). doi: 10.1007/978-3-030-30648-9_97

A Preliminary Comparison of P-Tool Consistency

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Keywords

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