Emergence and spread of a b.1.1.28-derived p.6 lineage with q675h and q677h spike mutations in uruguay

Natalia Rego, Cecilia Salazar, Mercedes Paz, Alicia Costábile, Alvaro Fajardo, Ignacio Ferrés, Paula Perbolianachis, Tamara Fernández-Calero, Veronica Noya, Matias R. Machado, Mariana Brandes, Rodrigo Arce, Mailen Arleo, Tania Possi, Natalia Reyes, María Noel Bentancor, Andrés Lizasoain, Viviana Bortagaray, Ana Moller, Odhille ChapposNicolas Nin, Javier Hurtado, Melissa Duquía, Maria Belén González, Luciana Griffero, Mauricio Méndez, Maria Pía Techera, Juan Zanetti, Emiliano Pereira, Bernardina Rivera, Matías Maidana, Martina Alonso, Pablo Smircich, Ighor Arantes, Daiana Mir, Cecilia Alonso, Julio Medina, Henry Albornoz, Rodney Colina, Gonzalo Bello, Pilar Moreno, Gonzalo Moratorio, Gregorio Iraola, Lucía Spangenberg

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5 Citas (Scopus)

Resumen

Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially in-creased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other depart-ments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest.

Idioma originalInglés
Número de artículo1801
PublicaciónViruses
Volumen13
N.º9
DOI
EstadoPublicada - set. 2021

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